Introduction: Nipahand Hendra viruses belong to the Paramyxoviridae family, which pose a significantthreat to human health, with sporadic outbreaks causing severe morbidity andmortality. Early symptoms include fever, cough, sore throat, and headache,which offer little in terms of differential diagnosis. There are no specifictherapeutics and vaccines for these viruses. Areas covered: Thisreview comprehensively covers a spectrum of diagnostic techniques for Nipah andHendra virus infections, discussed in conjunction with appropriate type ofsamples during the progression of infection. Serological assays, reversetranscriptase Real-Time PCR assays, and isothermal amplification assays arediscussed in detail, along with a listing of few commercially availabledetection kits. Patents protecting inventions in Nipah and Hendra virusdetection are also covered. Expert opinion: Despiteseveral outbreaks of Nipah and Hendra infections in the past decade, in-depth researchinto their pathogenesis, Point-of-Care diagnostics, specific therapies, andhuman vaccines is lacking. A prompt and accurate diagnosis is pivotal forefficient outbreak management, patient treat- ment, and the adoption ofpreventative measures. The emergence of rapid point-of-care tests holds promisein enhancing diagnostic capabilities in real-world settings. The patent landscapeemphasizes the importance of innovation and collaboration within the legal andbusiness realms.
